김경래
2017-02-21T01:36:15Z
2017-02-21T01:36:15Z
2015-06
TUMOR BIOLOGY, v. 36, NO 6, Page. 4387-4396
1010-4283
1423-0380
http://link.springer.com/article/10.1007%2Fs13277-015-3078-y
http://hdl.handle.net/20.500.11754/25559
Alcohol consumption is one of the major risk factors for head and neck squamous cell carcinoma (HNSCC), and the alcohol dehydrogenase (ADH) family proteins are key enzymes in ethanol metabolism. We examined the associations between single nucleotide polymorphisms (SNPs) of ADH1B and ADH1C and the risk of HNSCC. We analyzed six SNPS of ADH1B, namely -992C ˃ G, -957C ˃ A, +3170A ˃ G, +3377G ˃ T, +3491G ˃ A, and +13543A ˃ G, and five SNPs of ADH1C, namely -1064C ˃ T, -325G ˃ C, +5702A ˃ G, +7462T ˃ C, and +13044A ˃ G, in 260 Korean HNSCC patients and 330 controls, using single base extension and the TaqMan assay. The odds ratios (ORs) and 95 % confidence intervals (95 % CIs) of the CG and GG genotypes of ADH1B -992C ˃ G, the AA genotype of -957C ˃ A, the GG genotype of +3170A ˃ G, the GA genotype of +3491G ˃ A, and +13543A ˃ G were 0.51 (0.32-0.82), 0.63 (0.42-0.94), 1.84 (1.13-2.99), 1.77 (1.15-2.73), 2.34 (1.44-3.79), and 2.21 (1.23-3.95), respectively. The ORs of ADH1C +13044A ˃ G were 1.94 (1.01-3.71) and 1.97 (1.05-3.71) in the dominant and co-dominant models, respectively. The ORs of the GC genotype of ADH1C -325G ˃ C and the AG genotype of +5702A ˃ G were 2.52 (1.51-4.21) and 2.43 (1.36-4.32), respectively. ADH1B +3170A ˃ G and ADH1C +13044A ˃ G were in strong linkage disequilibrium with the other SNPs of ADH1B and ADH1C, respectively. There were gene-environment interactions between ADH1B +3170A ˃ G and ADH1C +13044A ˃ G and alcohol consumption and smoking. ADH1B +3170A ˃ G and ADH1C +13044A ˃ G SNPs are associated with an increased risk of HNSCC, and they could be used as biomarkers for the high-risk group of HNSCC in Koreans.
en
SPRINGER
Polymorphism
SNP
ADH1B
ADH1C
Head and neck cancer
Association between ADH1B and ADH1C polymorphisms and the risk of head and neck squamous cell carcinoma
Article
6
36
10.1007/s13277-015-3078-y
4387-4396
TUMOR BIOLOGY
Ji, Yong Bae
Lee, Seung Hwan
Kim, Kyung Rae
Park, Chul Won
Song, Chang Myeon
Park, Byung Lae
Shin, Hyoung Doo
Tae, Kyung
2015001496
S
COLLEGE OF MEDICINE[S]
DEPARTMENT OF MEDICINE
krkim