류재숙
2017-02-02T04:59:42Z
2017-02-02T04:59:42Z
2015-06
ASIAN JOURNAL OF ANDROLOGY, v. 17, NO 2, Page. 319-323
1008-682x
1745-7262
http://www.ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=2;spage=319;epage=323;aulast=Roh
http://hdl.handle.net/20.500.11754/25317
Trichomonas vaginalis infection is one of the most prevalent sexually transmitted infections in humans and is now recognized as an important cause of infertility in men. There is little information about the effect of extracellular polymeric substances (EPS) from T. vaginalis on sperm, but previous reports do not provide a conclusive description of the functional integrity of the sperm. To investigate the impact of EPS on the fertilizing capacity of sperm, we assessed sperm motility, acrosomal status, hypo-osmotic swelling, and in vitrofertilization rate after incubating the sperm with EPS in vitrousing mice. The incubation of sperm with EPS significantly decreased sperm motility, viability, and functional integrity in a concentration and time-dependent manner. These effects on sperm quality also resulted in a decreased fertilization rate in vitro. This is the first report that demonstrates the direct negative impact of the EPS of T. vaginalis on the fertilization rate of sperm in vitro. However, further study should be performed using human sperm to determine if EPS has similar negative impact on human sperm fertilizing capacity in vitro.
This study was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (No. 2009-0067578).
en
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
extracellular polymeric substances
fertilization
sperm
Trichomonas vaginalis
The secretory products of Trichomonas vaginalis decrease fertilizing capacity of mice sperm in vitro
Article
2
17
10.4103/1008-682X.145070
319-323
ASIAN JOURNAL OF ANDROLOGY
Roh, Jaesook
Lim, Young-Su
Seo, Min-Young
Choi, Yuri
Ryu, Jae-Sook
2015001251
S
COLLEGE OF MEDICINE[S]
DEPARTMENT OF MEDICINE
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