이종민
2017-01-09T05:10:39Z
2017-01-09T05:10:39Z
2015-05
HUMAN BRAIN MAPPING, v. 36, NO 5, Page. 1716-1727
1065-9471
1097-0193
http://onlinelibrary.wiley.com/doi/10.1002/hbm.22732/abstract;jsessionid=523D53BA5CA76A4946AAD9EFF618F8E7.f03t02
http://hdl.handle.net/20.500.11754/24985
Olfactory performance in Parkinson's disease (PD) is closely associated with subsequent cognitive decline. In the present study, we analyzed the olfaction-dependent functional connectivity with a hypothesis that olfactory performance would influence functional connectivity within key brain areas of PD. A total of 110 nondemented drug-naive patients with PD were subdivided into three groups of high score (PD-H, n=23), middle score (PD-M, n=64), and low score (PD-L, n=23) based on olfactory performance. We performed the resting-state functional connectivity with seed region of interest in the posterior cingulate cortex (PCC) and caudate. An analysis of functional connectivity revealed that PD-L patients exhibited a significant attenuation of cortical functional connectivity with the PCC in the bilateral primary sensory areas, right frontal areas, and right parietal areas compared to PD-H or PD-M patients. Meanwhile, PD-L patients exhibited a significant enhancement of striatocortical functional connectivity in the bilateral occipital areas and right frontal areas compared to PD-H or PD-M patients. In the voxel-wise correlation analysis, olfactory performance was positively associated with cortical functional connectivity with the PCC in similar areas of attenuated cortical connectivity in PD-L patients relative to PD-H patients. On the other hand, the cortical functional connectivity with the caudate was negatively correlated with olfactory performance in similar areas of increased connectivity in PD-L patients relative to PD-H patients. The present study demonstrated that resting state functional connectivity exhibits a distinctive pattern depending on olfactory performance, which might shed light on a meaningful relationship between olfactory impairment and cognitive dysfunction in PD. Hum Brain Mapp 36:1716-1727, 2015.
Contract grant sponsor: Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and future Planning; Contract grant number: NRF-2013R1A2A2A01067761; Contract grant sponsor: National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST); Contract grant number: 2011-0028333
en
WILEY-BLACKWELL
Parkinson's disease
resting state functional connectivity
olfaction
cognition
Olfactory Performance and Resting State Functional Connectivity in Non-demented Drug Naive Patients with Parkinson's Disease
Article
5
36
10.1002/hbm.22732
1716-1727
HUMAN BRAIN MAPPING
Sunwoo, Mun Kyung
Cha, Jungho
Ham, Jee Hyun
Song, Sook K.
Hong, Jin Yong
Lee, Jong-Min
Sohn, Young H.
Lee, Phil Hyu
2015001549
S
COLLEGE OF ENGINEERING[S]
DIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING
ljm