이규용
2016-09-23T04:32:06Z
2016-09-23T04:32:06Z
2015-03
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, v. 24, NO 3, Page. 704-710
1052-3057
http://www.sciencedirect.com/science/article/pii/S1052305714005801
http://hdl.handle.net/20.500.11754/23307
Background: Pre-existing silent brain infarctions (SBIs) have been reported to be associated with better outcomes after first-ever symptomatic ischemic stroke, although the mechanism of this remains unclear. We investigated the association between SBIs, outcomes of acute lacunar infarction, and biomarkers including vascular endothelial growth factor (VEGF), stromal cell-derived factor-1 alpha (SDF-1 alpha), macrophage migration inhibitory factor (MIF), and high-mobility group box-1 (HMGB1). Methods: A total of 68 consecutive patients diagnosed with first-ever lacunar infarction (˂20 mm) within 24 hours of symptom onset were included in this study. Clinical, laboratory, and imaging data were obtained. Plasma levels of VEGF, SDF-1 alpha, MIF, and HMGB1 were assessed using Enzyme-Linked Immunosorbent Assay kits. Results: SBIs were noted in 31 of the 68 patients. Although the initial National Institutes of Health Stroke Scale scores were not related with the presence of SBIs (P = .313), patients with SBIs had better outcomes at 3 months (P = .029). Additionally, plasma VEGF levels were higher (P = .035) and SDF-1 alpha levels were lower (P ˂ .001) in patients with SBIs. Logistic regression analysis indicated that VEGF and SDF-1 alpha were independently associated with the presence of SBIs. Conclusions: SBIs are associated with favorable outcomes in patients with first-ever acute lacunar infarction and higher levels of VEGF, and lower levels of SDF-1 alpha in these patients may contribute to their more favorable prognosis.
This work was supported by a grant 2012R1A1B3000473 from the Korea Research Foundation, Seoul, Korea.
en
ELSEVIER SCIENCE BV
VEGF
SDF-1a
silent infarction
lacunar infarction
Increased VEGF and Decreased SDF-1 alpha in Patients with Silent Brain Infarction Are Associated with Better Prognosis after First-Ever Acute Lacunar Stroke
Article
3
24
10.1016/j.jstrokecerebrovasdis.2014.11.021
704-710
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
Kwon, Hyuk Sung
Kim, Young Seo
Park, Hyun Hee
Choi, Hojin
Lee, Kyu-Yong
Lee, Young Joo
Heo, Sung Hyuk
Chang, Dae-Il
Koh, Seong-Ho
2015010859
S
COLLEGE OF MEDICINE[S]
DEPARTMENT OF MEDICINE
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