KUTZNER ARNE HOLGER
2019-12-04T05:50:16Z
2019-12-04T05:50:16Z
2018-01
BIOLOGICAL CHEMISTRY, v. 399, no. 1, page. 55-61
1431-6730
1437-4315
https://www.degruyter.com/view/j/bchm.2018.399.issue-1/hsz-2017-0190/hsz-2017-0190.xml
https://repository.hanyang.ac.kr/handle/20.500.11754/117229
Due to an aging society with an increased dementia-induced threat to higher cognitive functions, it has become imperative to understand the molecular and cellular events controlling the memory and learning processes in the brain. Here, we suggest that the novel master gene pair |-SRGAP2-FAM72-| (SLIT-ROBO Rho GTPase activating the protein 2, family with sequence similarity to 72) reveals a new dogma for the regulation of neural stem cell (NSC) gene expression and is a distinctive player in the control of human brain plasticity. Insight into the specific regulation of the brain-specific neural master gene |-SRGAP2-FAM72-| may essentially contribute to novel therapeutic approaches to restore or improve higher cognitive functions.
This study was supported by Hanyang University, which provided a scholarship to Ms. Nguyen Thi Thanh Ho, and by the Basic Science Research Program through the National Research Foundation of Korea (NRF), which was funded by the Ministry of Education (2015R1D1A1A01057243).
en_US
WALTER DE GRUYTER GMBH
brain
FAM72
learning
memory
neuron
p17
SRGAP2
synapse
Brain plasticity, cognitive functions and neural stem cells: a pivotal role for the brain-specific neural master gene
Article
1
399
10.1515/hsz-2017-0190
55-61
JOURNAL OF BIOLOGICAL CHEMISTRY
Nguyen Thi Thanh Ho
Kutzner, Arne
Heese, Klaus
2018001923
S
COLLEGE OF ENGINEERING[S]
DEPARTMENT OF INFORMATION SYSTEMS
kutzner