이창호
2019-11-25T07:54:08Z
2019-11-25T07:54:08Z
2017-06
MOLECULES AND CELLS, v. 40, no. 7, page. 485-494
1016-8478
0219-1032
http://www.molcells.org/journal/view.html?doi=10.14348/molcells.2017.0034
https://repository.hanyang.ac.kr/handle/20.500.11754/114237
Oleanolic acid (OA) has neurotrophic effects on neurons, although its use as a neurological drug requires further research. In the present study, we investigated the effects of OA and OA derivatives on the neuronal differentiation of rat hippocampal neural progenitor cells. In addition, we investigated whether the class II histone deacetylase (HDAC) 5 mediates the gene expression induced by OA. We found that OA and OA derivatives induced the formation of neurite spines and the expression of synapse-related molecules. OA and OA derivatives stimulated HDAC5 phosphorylation, and concurrently the nuclear export of HDCA5 and the expression of HDAC5 target genes, indicating that OA and OA derivatives induce neural differentiation and synapse formation via a pathway that involves HDAC5 phosphorylation.
This research was supported by a National Research Foundation of Korea (NRF) grant (No. 2016R1A2B2006474) funded by the Ministry of Education, Science and Technology (MEST), Republic of Korea and the research fund of Hanyang University(HY-2017) awarded to HS.
en_US
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
HDAC5
neuronal differentiation
oleanolic acid
Oleanolic Acid Promotes Neuronal Differentiation and Histone Deacetylase 5 Phosphorylation in Rat Hippocampal Neurons
Article
7
40
10.14348/molcells.2017.0034
485-494
MOLECULES AND CELLS
Jo, Hye-Ryeong
Wang, Sung Eun
Kim, Yong-Seok
Lee, Chang Ho
Son, Hyeon
2017002526
S
COLLEGE OF MEDICINE[S]
DEPARTMENT OF MEDICINE
jennysue