채필석
2019-05-09T07:07:10Z
2019-05-09T07:07:10Z
2019-02
SENSORS AND ACTUATORS B-CHEMICAL, v. 281, Page. 933-944
0925-4005
https://www.sciencedirect.com/science/article/pii/S0925400518319774?via%3Dihub
https://repository.hanyang.ac.kr/handle/20.500.11754/103684
Six thiophene-bis(benzimidazole)-based molecular probes with tunable fluorescence emission were synthesized for selective Hg2+ detection. Probe 1 contains a thiophene-bis(benzimidazole) unit without an appendage, while probes 2-4 have multiple appendages on benzimidazole rings of the core and probe 6/7 has two biphenyl appendages on the thiophene ring. Fluorescence emissions of all these probes were selectively quenched upon Hg2+ addition, but probe 7 provided the most sensitive detection of Hg2+, giving the highest association constant (K-a (7) = 2.38 x 10(6) M-1) and the lowest observed and calculated limit of detections (LODs) (5 nM and 0.047 pM, respectively). Thus, the probe 7-Hg2+ complex was further tested for detection of a biomolecule as a next step. Among the various biomolecules tested (including amino acids), L-lysine (Lys) uniquely showed a full restoration of the fluorescence intensity of [probe 7 + Hg2+ (1:2)]-complex to the level of the free probe, with an LOD of 5 nM. Thus, a cascade detection of Hg2+ and Lys was attained by probe 7 via selective quenching and recovering of the fluorescence intensity, which enables us to build an "ON-OFF-ON" switch and logic gate at a molecular level. The current system was fully studied by various analytical methods such as UV-vis, fluorescence, and H-1 NMR spectroscopies, IR, FE-SEM images, and DFT calculations.
This work was supported by the research fund of Hanyang University (HY-2018-N).
en
ELSEVIER SCIENCE SA
Thiophene-bis(benzimidazole)
Hg2+
Lysine
ON-OFF-ON
Switch
Logic gate
Fluorescence tunable thiophene-bis(benzimidazole)-based probes for a cascade trace detection of Hg2+ and lysine: A molecular switch mimic
Article
281
10.1016/j.snb.2018.11.023
933-944
SENSORS AND ACTUATORS B-CHEMICAL
Kumar, Ashwani
Chae, Pil Seok
2019002468
S
GRADUATE SCHOOL[S]
DEPARTMENT OF BIONANOTECHNOLOGY
pchae
http://orcid.org/0000-0003-1799-3304